An individual-level data synthesis of Clinical Trials Network studies to examine the impact of psychosocial treatments for Black people who use cocaine and/or opioids
09/2025
Journal Article
Authors:
Burlew, A. K.;
Ruglass, L. M.;
Espinosa, A.;
McCuistian, C.;
Haeny, A. M.;
Jordan, A.;
Roundtree, C.;
Lopez, J.;
Vena, A.;
Morgan-Lopez, A. A.
Volume:
276
Journal:
Drug Alcohol Depend
PMID:
40902223
URL:
https://www.ncbi.nlm.nih.gov/pubmed/40902223
DOI:
10.1016/j.drugalcdep.2025.112850
Keywords:
Black/African American Integrative data analysis NIDA Clinical Trials Network Stimulants Substance use treatment Treatment effectiveness
Abstract:
OBJECTIVE: Cocaine- and opioid-related overdose deaths have increased among Black people, which makes identifying effective treatments for Black people a high priority. We investigated the comparative effectiveness of behavioral treatments among Black adults who use cocaine and/or opioids. METHODS: Identified multisite randomized clinical trials (RCTs) of behavioral interventions that targeted substance use, had participants who self-identified as Black, and included cocaine use outcome measures from the National Drug Abuse Treatment Clinical Trials Network (CTN) datashare. We estimated cocaine use and opioid use severity scale scores while considering study-level measurement non-invariance. Then, we estimated the inverse probability of treatment-weighted (IPTW) linear mixed models to assess comparative effectiveness of treatments that address social-contextual factors and those focused solely on substance use (e.g., contingency management (CM)) relative to treatment-as-usual/controls on cocaine use and opioid use severity scores during- and post-treatment. RESULTS: Nine RCTs met inclusion criteria, with a combined sample of 1381 Black adults who used cocaine and/or opioids. The IPTW linear mixed models indicated that cocaine use severity decreased from baseline to end-of-treatment across three treatment groups, with a greater decrease for social-contextual treatments and CM relative to treatment-as-usual/controls. However, this greater reduction was maintained at 12-month follow-ups for social-contextual treatments, while CM worsened relative to TAU/controls. We found decreases in latent opioid use severity with no or minor differences between treatment groups. CONCLUSIONS: The findings suggest that addressing social-contextual factors is an essential treatment component for long-term reduction of cocaine use among Black adults.