The Society of Pediatric Liver Transplantation (SPLIT): 2023 Registry Status
06/2025
Journal Article
Authors:
Banc-Husu, A. M.;
Smith, R.;
Kelly, B.;
Anand, R.;
Anderson, S. G.;
Lobritto, S.;
Chapin, C. A.;
Chartier, M. E.;
Ekong, U. D.;
Elisofon, S. A.;
Feldman, A.;
Furuya, K. N.;
Garcia, J.;
Gonzalez-Peralta, R.;
Gutierrez Sanchez, L. H.;
Hildreth, A.;
Himes, R.;
Ibrahim, S. H.;
Jain, A.;
Kerkar, N.;
Leung, D. H.;
Mazareigos, G.;
Ng, V. L.;
Pai, A.;
Pan, D. H.;
Peters, A. L.;
Shakhin, V.;
Stoll, J.;
Wadera, S.;
Hsu, E.;
Squires, J. E.;
Valentino, P. L.;
Society of Pediatric Liver, Transplantation
Volume:
29
Issue:
5
Journal:
Pediatr Transplant
PMID:
40522021
URL:
https://www.ncbi.nlm.nih.gov/pubmed/40522021
Keywords:
Humans *Liver Transplantation/mortality *Registries Infant Female Male Child Child, Preschool Adolescent Treatment Outcome Societies, Medical Infant, Newborn Retrospective Studies children liver transplantation outcomes
Abstract:
BACKGROUND: The Society of Pediatric Liver Transplantation (SPLIT) has undergone tremendous growth with > 45 sites contributing data focusing on improving outcomes in pediatric liver transplantation (LT). We report and compare outcomes from the SPLIT Registry. METHODS: Patients < 18 years with first-time LT only enrolled into the SPLIT Registry between 2011 and 2023 were included. Data was stratified into eras from the last published registry update (era 1: 2011-2018, era 2: 2018-2023). RESULTS: Three thousand five hundred four participants from 47 centers were included (era 1: n = 2159; era 2: n = 1345). Age distribution differed with more children < 1 year. of age at LT in era 2 (era 1: 29% vs. era 2: 33%, p = 0.01). Indications for LT were similar, with biliary atresia (38.8%) and metabolic disease (16.0%) being most common. Exception point use was higher in era 2 (era 1: 45% vs. era 2: 56%, p < 0.001). No difference in graft type (deceased: 81% era 1 vs. 78% era 2, p = 0.78), patient survival at 90 days (era 1: 98.7% vs. era 2: 98.3%), 1 year (era 1: 97.2 vs. era 2: 96.8%), or 3 years (era 1: 95.3% vs. era 2: 95.2%) was noted. Rate of hepatic artery thrombosis was lower in era 2 (era 1: 7% vs. era 2: 5%, p = 0.02). CONCLUSIONS: Trends in pediatric LT within SPLIT note similar LT indications and graft type, higher utilization of exception points, and lower HAT rates despite transplanting more children < 10 kg. This data underscores the evolution of pediatric LT toward higher survivability and overall patient outcomes.