Liver Transplant Outcomes in HIV(+) Haemophilic Men
Jan-13
Journal Article
Authors:
Ragni, M.V.;
Devera, M.E.;
Roland, M.E.;
Wong, M.;
Stosor, V.;
Sherman, K.E.;
Hardy, D.;
Blumberg, E.;
Fung, J.;
Barin, B.;
Stablein, D.;
Stock, P.G.
Secondary:
Haemophilia
Volume:
19
Pagination:
134-140
URL:
http://www.ncbi.nlm.nih.gov/pubmed/22762561
Keywords:
haemophilia; hepatitis C liver disease; HIV-HCV co-infection; liver transplantation
Abstract:
<p>{Hepatitis C virus infection is the major cause of end-stage liver disease and the major indication for transplantation (OLTX), including among HIV-HCV co-infected individuals. The age of HCV acquisition differs between haemophilic and non-haemophilic candidates, which may affect liver disease outcomes. The purpose of the study was to compare rates of pre- and post-OLTX mortality between co-infected haemophilic and non-haemophilic subjects without hepatocellular cancer participating in the Solid Organ Transplantation in HIV Study (HIV-TR). Clinical variables included age, gender, race, liver disease aetiology, BMI, antiretroviral therapy, MELD score, CD4 + cell count, HIV RNA PCR and HCV RNA PCR. Time to transplant, rejection and death were determined. Of 104 HIV-HCV positive subjects enrolled, 34 (32.7%) underwent liver transplantation, including 7 of 15 (46.7%) haemophilic and 27 of 89 (30.3%) non-haemophilic candidates. Although haemophilic subjects were younger, median 41 vs. 47 years</p>