Go back to Resources

Liver Transplant Outcomes in HIV(+) Haemophilic Men

Jan-13

Journal Article

Authors:

Ragni, M.V.

Devera, M.E.

Roland, M.E.

Wong, M.

Stosor, V.

Sherman, K.E.

Hardy, D.

Blumberg, E.

Fung, J.

Barin, B.

Stablein, D.

Stock, P.G.

Secondary:
Haemophilia

Volume:
19

Pagination:
134-140

URL:
http://www.ncbi.nlm.nih.gov/pubmed/22762561

Keywords:
haemophilia; hepatitis C liver disease; HIV-HCV co-infection; liver transplantation

Abstract:
<p>{Hepatitis C virus infection is the major cause of end-stage liver disease and the major indication for transplantation (OLTX), including among HIV-HCV co-infected individuals. The age of HCV acquisition differs between haemophilic and non-haemophilic candidates, which may affect liver disease outcomes. The purpose of the study was to compare rates of pre- and post-OLTX mortality between co-infected haemophilic and non-haemophilic subjects without hepatocellular cancer participating in the Solid Organ Transplantation in HIV Study (HIV-TR). Clinical variables included age, gender, race, liver disease aetiology, BMI, antiretroviral therapy, MELD score, CD4 + cell count, HIV RNA PCR and HCV RNA PCR. Time to transplant, rejection and death were determined. Of 104 HIV-HCV positive subjects enrolled, 34 (32.7%) underwent liver transplantation, including 7 of 15 (46.7%) haemophilic and 27 of 89 (30.3%) non-haemophilic candidates. Although haemophilic subjects were younger, median 41 vs. 47 years</p>

Go back to Resources