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Safety and Immunogenicity of a Single Low Dose or High Dose of Clade 2 Influenza A(H5N1) Inactivated Vaccine in Adults Previously Primed With Clade 1 Influenza A(H5N1) Vaccine

Aug-15

Journal Article

Authors:

Winokur, P.L.

Patel, S.M.

Brady, R.

Chen, W.H.

El-Kamary, S.S.

Edwards, K.

Creech, C.B.

Frey, S.

Keitel, W.A.

Belshe, R.

Walter, E.

Bellamy, A.

Hill, H.

Group, T.V.T.E.U.H.3Nv

Secondary:
J Infect Dis

Volume:
212

Pagination:
525-530

URL:
http://www.ncbi.nlm.nih.gov/pubmed/25712967

Keywords:
H5n1; influenza; prime-boost; vaccine

Abstract:
<p>Influenza A(H5N1) vaccination strategies that improve the speed of the immunological response and cross-clade protection are desired. We compared the immunogenicity of a single 15-mug or 90-mug dose of A/H5N1/Indonesia/05/05 (clade 2) vaccine in adults who were previously primed with A/H5N1/Vietnam/1203/2004 (clade 1) vaccine. High-dose vaccine resulted in significantly higher titers to both clade 1 and 2 antigens. Clade 2 titers were unaffected by the previous dose of clade 1 vaccine. Low-dose priming with a mismatched pandemic influenza A(H5N1) vaccine would improve the rapidity, magnitude, and cross-reactivity of the immunological response following a single high-dose, unadjuvanted, pandemic vaccine.</p>

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